HER Imaging and Molecular Interaction Mapping in Breast Cancer
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Dissemination - Abstracts and Publications


Abstracts
1 PR Barber, IDC Tullis, MI Rowley, K Lawler, G Weitsman, T Ng and B Vojnovic. FLIM Histology: Detecting protein interactions in human tissue by FRET.
Presentation at the Microscience Microscopy Congress (tmmc2015); July 2015
View about the meeting; abstract to follow
2 Gregory Weitsman, Paul R Barber, Katherine Lawler, Cheryl Gillett, Natalie Woodman, Boris Kholodenko, Lan K. Nguyen, Tapesh Santra, Borivoj Vojnovic and Tony Ng. Her2-3 heterodimers is a new and better then HER2 IHC score for clinical outcome prognosis.
Presentation at the 26th EORTC-NCI-ACR symposium on "Molecular targets and Cancer therapeutics", in Barcelona, 18-21 November 2014
View abstract
3 Livanos M, Bhavsar G, Nagy G, Plückthun A, Tolner B and Chester K. Production of Proteins using the Yeast Pichia pastoris: Interfacing Fermentation and Radial Flow Bed IMAC Primary Capture.
Poster Session at the Pichia 2014 Protein Expression Conference 2-5 March, 2014 in Can Diego, USA.
Poster: view poster and abstract
4 Goldstein R, Meyer T, Tolner B, Chester K, Livanos M, Vigor K, Bhavsar G, Sosabowski J, Mather S, Leyton J, Plückthun A and Nagy G. Developing Designed Ankyrin Repeat Proteins (DARPins) for HER2 imaging.
Poster Session at the 2013 NCRI Cancer Conference 3-6 November, 2013 in Liverpool, UK.
Poster B8: view poster or online at NCRI
5 Goldstein R, Tolner B, Leyton J, Livanos M, Bhavsar G, Vigor K, Nagy G, Mather S, Plückthun A, Sosabowski J, Meyer T, and Chester K. Pre-clinical developments of the G3 Designed ankyrin repeat protein (DARPin) for in vivo assessment of HER2 expression.
Poster Session at the American Association for Cancer Research Annual Meeting 9 April, 2013 in Washington, DC and published in the 2013 Proceedings of the AACR; Abstract 3912; Cancer Research: April 15, 2013; Volume 73, Issue 8, Supplement 1; doi: 10.1158/1538-7445.AM2013-3912 ; Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC.
Poster;  Abstract 3912

Publications
1 Barber, P., Rowley, M.I., Lawler, K., Weitsman, G., Ng, T., Vojnovic, B. A Processing Pipeline for Detecting Protein Interactions in Histological Tissue Medical Image Understanding and Analysis Conference (MIUA) 2015 (in press). Online.
2 K. Lawler, E. Papouli, A. Tutt, T. Ng, S. Pinder, P. Parker, L. Holmberg, C. Gillett, A. Grigoriadis and A. Purushotham A Clinical patterns of metastatic spread from formalin-fixed, paraffin-embedded (FFPE) expression profiles: A case-control study of 1,357 breast cancer patients Annals of Oncology 2015, 26 (Supplement 3): iii10-iii14. Online.
3 Goldstein R, Sosabowski J, Livanos M, Leyton J, Vigor K, Bhavsar G, Nagy-Davidescu G, Rashid M, Miranda E, Yeung J, Tolner B, Plückthun A, Mather S, Meyer T, Chester K. Development of the designed ankyrin repeat protein (DARPin) G3 for HER2 molecular imaging. Eur J Nucl Med Mol Imaging (2015), 42:288-301. Online.
4 Ng, T., Weitsman, G., Barber, P., Lawler, K., Rowley, M., Elshtein, G. et al. Use of FLIM histology-based HER2-HER3 heterodimer quantification and a Bayesian latent class proportional hazards model to predict cetuximab response in the COIN and new EPOC trials. J Clin Oncol 33, 2015 (suppl; abstr e14535). Online.
5 Weitsman G, Lawler K, Kelleher MT, Barrett JE, Barber PR, Shamil E, Festy F, Patel G, Fruhwirth G, Huang L, Tullis ID, Woodman N, Ofo E, Ameer-Beg SM, Irshad S, Condeelis J, Gillett CE, Ellis PA, Vojnovic B, Coolen AC, Ng T. Imaging tumour heterogeneity of the consequences of a PKCa-substrate interaction in breast cancer patients Biochem Soc Trans. (2014) 42:1498-505. Online.
6 Claus J, Patel G, Ng T, Parker PJ. A role for the pseudokinase HER3 in the acquired resistance against EGFR- and HER2-directed targeted therapy. Biochem Soc Trans. (2014) 42:831-6. Online.
7 Beck S and Ng T. C2c: turning cancer into chronic disease. Genome Medicine (2014), 6:38. Online.
8 Schubert W. Systematic, spatial imaging of large multimolecular assemblies and the emerging principles of supramolecular order in biological systems. J Mol Recognit (2014) 27(1):3-18. Online
9 Tao JJ1, Castel P, Radosevic-Robin N, Elkabets M, Auricchio N, Aceto N, Weitsman G, Barber P, Vojnovic B, Ellis H, Morse N, Viola-Villegas NT, Bosch A, Juric D, Hazra S, Singh S, Kim P, Bergamaschi A, Maheswaran S, Ng T, Penault-Llorca F, Lewis JS, Carey LA, Perou CM, Baselga J and Scaltriti M. Antagonism of EGFR and HER3 Enhances the Response to Inhibitors of the PI3K-Akt Pathway in Triple-Negative Breast Cancer. Science Signaling (2014) 7(318). Online
10 Barber P R ; Tullis IDC, Rowley MI, Martins CD, Weitsman G, Lawler K, Coffey M, Woodman N, Gillett CE, Ng T and Vojnovic B. The Gray Institute open microscopes applied to radiobiology and protein interaction studies.
Proc SPIE 8949, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXI, 89490D. (2014); Online
11 Chowdhury R, Ganeshan B, Irshad S, Lawler K, Eisenblatter M, Milewicz H, Rodriguez-Justo M, Miles K, Ellis P, Groves A, Punwani S, Ng T. The use of molecular imaging combined with genomic techniques to understand the heterogeneity in cancer metastasis. The British Journal of Radiology (2014), 87 (1038). Online
12 Schubert W. In and contributions to Encyclopedia of Systems Biology. (2013) Edited by Dubitzky W, Wolkenhauer O, Cho KH and Yokota H.
Chapters contributed: Schubert W, Toponomics; Gieseler A, Synaptic toponome; Gieseler A, Synaptic proteins; Hillert R, Combinatorial Molecular Phenotype; Hillert R, Toponome Analysis; Krusche A, TIS robot.
Online: SBN: 978-1-4419-9862-0 (Print) 978-1-4419-9863-7 (Online), or click here.
13 Goldstein R, Sosabowski J, Vigor K, Chester K, Meyer T. Developments in single photon emission computed tomography and PET-based HER2 molecular imaging for breast cancer. Expert Rev Anticancer Ther (2013), 13(3): 359-373. Online
14 James Barrett J and Coolen ACC. Dimensionality Detection and Integration of Multiple Data Sources via the GP-LVM. Journal of Machine Learning Research (2013), 1-48. Online
15 Schubert W, Gieseler A, Krusche A, Serocka P, Hillert R. Next generation biomarkers based on 100 parameter functional superresolution microscopy TIS. N Biotechnol (2012), 29, 599610.
16 Oelze S, Freiler W, Hillert R, Doleisch H, Preim B & Schubert W. Interactive, graphbased visual analysis of highdimensional, multiparamter fluorescence microscopy data in toponomics. IEEE Trans Vis Comput Graph. (2011), 17, 1882 – 1891.
 


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